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    Major adverse events are uncommon in these subjects in spite of long-term, high dose cross-sex steroid treatments. We describe the occurrence of a meningioma in a transwoman treated with estrogens and CPA over a period of nine years. The meningioma was revealed during a magnetic resonance imaging MRI scan performed as follow-up of a previous surgery for ganglioglioma. CPA intake was discontinued and tumor resection was performed.

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    Histological diagnosis confirmed a strong progesterone receptor-positive transwoman dating site slight estrogen positive meningioma. After surgery, the patient continued her treatment with leuprorelina acetate and estradiol.

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    At one-year follow-up, the MRI scan reveals no recurrence of the tumor. This is the ninth case in literature of a meningioma in a transwoman treated with estrogens and CPA, confirming a possible association between female sex steroids and meningioma.

    Although there is no still strong evidence of an association between meningioma and CPA, this report may suggest use of alternative treatment for transwomen.

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    This report highlights the importance to record all the cases of meningiomas in high dose CPA-users, in order to improve data.